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» The ASTRAL compendium for protein structure and sequence ana...
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BMCBI
2010
86views more  BMCBI 2010»
13 years 7 months ago
Mining protein loops using a structural alphabet and statistical exceptionality
Background: Protein loops encompass 50% of protein residues in available three-dimensional structures. These regions are often involved in protein functions, e.g. binding site, ca...
Leslie Regad, Juliette Martin, Grégory Nuel...
BMCBI
2010
153views more  BMCBI 2010»
13 years 7 months ago
Analysis of substructural variation in families of enzymatic proteins with applications to protein function prediction
Background: Structural variations caused by a wide range of physico-chemical and biological sources directly influence the function of a protein. For enzymatic proteins, the struc...
Drew H. Bryant, Mark Moll, Brian Y. Chen, Viachesl...
BMCBI
2010
95views more  BMCBI 2010»
13 years 7 months ago
Quantifying the relationship between sequence and three-dimensional structure conservation in RNA
Background: In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two de...
Emidio Capriotti, Marc A. Martí-Renom
APBC
2003
138views Bioinformatics» more  APBC 2003»
13 years 9 months ago
A New Approach to Protein Structure and Function Analysis Using Semi-structured Databases
The development of high-throughput genome sequencing and protein structure determination techniques have provided researchers with a wealth of biological data. Integrated analysis...
William M. Shui, Raymond K. Wong, Stephen C. Graha...
CSB
2002
IEEE
103views Bioinformatics» more  CSB 2002»
14 years 13 days ago
Protein-Based Analysis of Alternative Splicing in the Human Genome
Understanding the functional significance of alternative splicing and other mechanisms that generate RNA transcript diversity is an important challenge facing modern-day molecular...
Ann E. Loraine, Gregg A. Helt, Melissa S. Cline, M...