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BMCBI
2008
117views more  BMCBI 2008»
13 years 9 months ago
Using a logical model to predict the growth of yeast
Background: A logical model of the known metabolic processes in S. cerevisiae was constructed from iFF708, an existing Flux Balance Analysis (FBA) model, and augmented with inform...
Ken E. Whelan, Ross D. King
BMCBI
2010
126views more  BMCBI 2010»
13 years 6 months ago
Systematic integration of experimental data and models in systems biology
Background: The behaviour of biological systems can be deduced from their mathematical models. However, multiple sources of data in diverse forms are required in the construction ...
Peter Li, Joseph O. Dada, Daniel Jameson, Irena Sp...
BMCBI
2008
242views more  BMCBI 2008»
13 years 9 months ago
New time-scale criteria for model simplification of bio-reaction systems
Background: Quasi-steady state approximation (QSSA) based on time-scale analysis is known to be an effective method for simplifying metabolic reaction system, but the conventional...
Junwon Choi, Kyung-won Yang, Tai-yong Lee, Sang Yu...
BMCBI
2011
13 years 3 months ago
Hierarchical graphs for rule-based modeling of biochemical systems
Background: In rule-based modeling, graphs are used to represent molecules: a colored vertex represents a component of a molecule, a vertex attribute represents the internal state...
Nathan W. Lemons, Bin Hu, William S. Hlavacek
WSC
2008
13 years 11 months ago
Experience in the broadening of a single-purpose simulation model
Simulation models are often developed for a single purpose. However, once a model is accepted by management and other stake-holders, it is quite common and desirable to wish to br...
Reid L. Kress, Pete Bereolos, Karen Bills, James C...