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BMCBI
2006
137views more  BMCBI 2006»
13 years 8 months ago
A classification-based framework for predicting and analyzing gene regulatory response
Background: We have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...
Anshul Kundaje, Manuel Middendorf, Mihir Shah, Chr...
BMCBI
2006
117views more  BMCBI 2006»
13 years 8 months ago
The Cluster Variation Method for Efficient Linkage Analysis on Extended Pedigrees
Background: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are exc...
Cornelis A. Albers, Martijn A. R. Leisink, Hilbert...
BMCBI
2006
144views more  BMCBI 2006»
13 years 8 months ago
methBLAST and methPrimerDB: web-tools for PCR based methylation analysis
Background: DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methy...
Filip Pattyn, Jasmien Hoebeeck, Piet Robbrecht, Ev...
BMCBI
2006
127views more  BMCBI 2006»
13 years 8 months ago
Construction of phylogenetic trees by kernel-based comparative analysis of metabolic networks
Background: To infer the tree of life requires knowledge of the common characteristics of each species descended from a common ancestor as the measuring criteria and a method to c...
Sok June Oh, Je-Gun Joung, Jeong Ho Chang, Byoung-...
BMCBI
2006
117views more  BMCBI 2006»
13 years 8 months ago
A method for estimation of elasticities in metabolic networks using steady state and dynamic metabolomics data and linlog kineti
Background: Dynamic modeling of metabolic reaction networks under in vivo conditions is a crucial step in order to obtain a better understanding of the (dis)functioning of living ...
I. Emrah Nikerel, Wouter A. van Winden, Walter M. ...
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