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» The Context-Dependence of Amino Acid Properties
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BMCBI
2008
149views more  BMCBI 2008»
13 years 7 months ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal
BMCBI
2008
158views more  BMCBI 2008»
13 years 7 months ago
Real value prediction of protein solvent accessibility using enhanced PSSM features
Background: Prediction of protein solvent accessibility, also called accessible surface area (ASA) prediction, is an important step for tertiary structure prediction directly from...
Darby Tien-Hao Chang, Hsuan-Yu Huang, Yu-Tang Syu,...
BMCBI
2004
150views more  BMCBI 2004»
13 years 7 months ago
Inter-residue distances derived from fold contact propensities correlate with evolutionary substitution costs
Background: The wealth of information on protein structure has led to a variety of statistical analyses of the role played by individual amino acid types in the protein fold. In p...
Gareth Williams, Patrick Doherty
BMCBI
2011
13 years 2 months ago
Simulated evolution applied to study the genetic code optimality using a model of codon reassignments
Background: As the canonical code is not universal, different theories about its origin and organization have appeared. The optimization or level of adaptation of the canonical ge...
Jose Santos, Ángel Monteagudo
AINA
2007
IEEE
13 years 11 months ago
Crick's Hypothesis Revisited: The Existence of a Universal Coding Frame
In 1957 Crick hypothesized that the genetic code was a comma free code. This property would imply the existence of a universal coding frame and make the set of coding sequences a ...
Jean-Louis Lassez, Ryan A. Rossi, Axel E. Bernal