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» The Equivalence of Sampling and Searching
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BMCBI
2011
13 years 2 months ago
Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
PKDD
2009
Springer
95views Data Mining» more  PKDD 2009»
14 years 2 months ago
Non-redundant Subgroup Discovery Using a Closure System
Subgroup discovery is a local pattern discovery task, in which descriptions of subpopulations of a database are evaluated against some quality function. As standard quality functio...
Mario Boley, Henrik Grosskreutz
BMCBI
2010
154views more  BMCBI 2010»
13 years 7 months ago
Binary image representation of a ligand binding site: its application to efficient sampling of a conformational ensemble
Background: Modelling the ligand binding site of a protein is an important component of understanding proteinligand interactions and is being actively studied. Even if the side ch...
Edon Sung, Sangsoo Kim, Whanchul Shin
UAI
2003
13 years 9 months ago
On Local Optima in Learning Bayesian Networks
This paper proposes and evaluates the k-greedy equivalence search algorithm (KES) for learning Bayesian networks (BNs) from complete data. The main characteristic of KES is that i...
Jens D. Nielsen, Tomás Kocka, José M...
CP
2004
Springer
14 years 1 months ago
Heuristic Selection for Stochastic Search Optimization: Modeling Solution Quality by Extreme Value Theory
The success of stochastic algorithms is often due to their ability to effectively amplify the performance of search heuristics. This is certainly the case with stochastic sampling ...
Vincent A. Cicirello, Stephen F. Smith