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BMCBI
2010
177views more  BMCBI 2010»
13 years 10 months ago
Clustering of protein families into functional subtypes using Relative Complexity Measure with reduced amino acid alphabets
Background: Phylogenetic analysis can be used to divide a protein family into subfamilies in the absence of experimental information. Most phylogenetic analysis methods utilize mu...
Aydin Albayrak, Hasan H. Otu, Ugur O. Sezerman
BMCBI
2008
122views more  BMCBI 2008»
13 years 10 months ago
Determining gene expression on a single pair of microarrays
Background: In microarray experiments the numbers of replicates are often limited due to factors such as cost, availability of sample or poor hybridization. There are currently fe...
Robert W. Reid, Anthony A. Fodor
MP
2006
138views more  MP 2006»
13 years 10 months ago
A new ILP-based refinement heuristic for Vehicle Routing Problems
In the paper we address the Distance-Constrained Capacitated Vehicle Routing Problem (DCVRP), where k minimum-cost routes through a central depot have to be constructed so as to co...
Roberto De Franceschi, Matteo Fischetti, Paolo Tot...
BMCBI
2005
137views more  BMCBI 2005»
13 years 9 months ago
A configuration space of homologous proteins conserving mutual information and allowing a phylogeny inference based on pair-wise
Background: Popular methods to reconstruct molecular phylogenies are based on multiple sequence alignments, in which addition or removal of data may change the resulting tree topo...
Olivier Bastien, Philippe Ortet, Sylvaine Roy, Eri...
BMCBI
2004
125views more  BMCBI 2004»
13 years 9 months ago
A functional hierarchical organization of the protein sequence space
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...
Noam Kaplan, Moriah Friedlich, Menachem Fromer, Mi...