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» The Pfam protein families database
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NAR
2007
132views more  NAR 2007»
13 years 7 months ago
Expanded protein information at SGD: new pages and proteome browser
The recent explosion in protein data generated from both directed small-scale studies and largescale proteomics efforts has greatly expanded the quantity of available protein info...
Robert S. Nash, Shuai Weng, Benjamin C. Hitz, Rama...
BMCBI
2011
12 years 11 months ago
GPCR-SSFE: A comprehensive database of G-protein-coupled receptor template predictions and homology models
Background: G protein-coupled receptors (GPCRs) transduce a wide variety of extracellular signals to within the cell and therefore have a key role in regulating cell activity and ...
Catherine L. Worth, Annika Kreuchwig, Gunnar Klein...
JIB
2006
106views more  JIB 2006»
13 years 7 months ago
A structural keystone for drug design
3D-structures of proteins and potential ligands are the cornerstones of rational drug design. The first brick to build upon is selecting a protein target and finding out whether b...
Kristian Rother, Mathias Dunkel, Elke Michalsky, S...
BIBM
2008
IEEE
125views Bioinformatics» more  BIBM 2008»
13 years 9 months ago
On the Role of Local Matching for Efficient Semi-supervised Protein Sequence Classification
Recent studies in protein sequence analysis have leveraged the power of unlabeled data. For example, the profile and mismatch neighborhood kernels have shown significant improveme...
Pavel P. Kuksa, Pai-Hsi Huang, Vladimir Pavlovic
RECOMB
2002
Springer
14 years 7 months ago
Combining pairwise sequence similarity and support vector machines for remote protein homology detection
One key element in understanding the molecular machinery of the cell is to understand the meaning, or function, of each protein encoded in the genome. A very successful means of i...
Li Liao, William Stafford Noble