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BMCBI
2008
100views more  BMCBI 2008»
13 years 7 months ago
PatternLab for proteomics: a tool for differential shotgun proteomics
Background: A goal of proteomics is to distinguish between states of a biological system by identifying protein expression differences. Liu et al. demonstrated a method to perform...
Paulo C. Carvalho, Juliana S. G. Fischer, Emily I....
BMCBI
2008
87views more  BMCBI 2008»
13 years 7 months ago
Volume-based solvation models out-perform area-based models in combined studies of wild-type and mutated protein-protein interfa
Background: Empirical binding models have previously been investigated for the energetics of protein complexation (G models) and for the influence of mutations on complexation (i....
Salim Bougouffa, Jim Warwicker
BMCBI
2008
78views more  BMCBI 2008»
13 years 7 months ago
Deducing topology of protein-protein interaction networks from experimentally measured sub-networks
Background: Protein-protein interaction networks are commonly sampled using yeast two hybrid approaches. However, whether topological information reaped from these experimentallym...
Ling Yang, Thomas M. Vondriska, Zhangang Han, W. R...
BMCBI
2008
141views more  BMCBI 2008»
13 years 7 months ago
Ontology-guided data preparation for discovering genotype-phenotype relationships
Complexity of post-genomic data and multiplicity of mining strategies are two limits to Knowledge Discovery in Databases (KDD) in life sciences. Because they provide a semantic fr...
Adrien Coulet, Malika Smaïl-Tabbone, Pascale ...
BMCBI
2008
102views more  BMCBI 2008»
13 years 7 months ago
Monitoring the evolutionary aspect of the Gene Ontology to enhance predictability and usability
Background: Much effort is currently made to develop the Gene Ontology (GO). Due to the dynamic nature of information it addresses, GO undergoes constant updates whose results are...
Jong C. Park, Tak-eun Kim, Jinah Park
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