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BMCBI
2011
15 years 1 months ago
Identifying hypermethylated CpG islands using a quantile regression model
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understandin...
Shuying Sun, Zhengyi Chen, Pearlly Yan, Yi-Wen Hua...
BMCBI
2010
114views more  BMCBI 2010»
15 years 6 months ago
Detecting variants with Metabolic Design, a new software tool to design probes for explorative functional DNA microarray develop
Background: Microorganisms display vast diversity, and each one has its own set of genes, cell components and metabolic reactions. To assess their huge unexploited metabolic poten...
Sébastien Terrat, Eric Peyretaillade, Olivi...
BMCBI
2007
109views more  BMCBI 2007»
15 years 6 months ago
A cis-regulatory logic simulator
Background: A major goal of computational studies of gene regulation is to accurately predict the expression of genes based on the cis-regulatory content of their promoters. The d...
Robert D. Zeigler, Jason Gertz, Barak A. Cohen
BMCBI
2008
99views more  BMCBI 2008»
15 years 6 months ago
Exhaustive prediction of disease susceptibility to coding base changes in the human genome
Background: Single Nucleotide Polymorphisms (SNPs) are the most abundant form of genomic variation and can cause phenotypic differences between individuals, including diseases. Ba...
Vinayak Kulkarni, Mounir Errami, Robert Barber, Ha...
ALIFE
2005
15 years 6 months ago
Transient Phenomena in Learning and Evolution: Genetic Assimilation and Genetic Redistribution
Deacon has recently proposed that complexes of genes can be integrated into functional groups as a result of environmental changes that mask and unmask selection pressures. For exa...
Janet Wiles, James Watson, Bradley Tonkes, Terrenc...