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BMCBI
2008
106views more  BMCBI 2008»
15 years 6 months ago
SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi,
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
BMCBI
2006
130views more  BMCBI 2006»
15 years 6 months ago
CARMA: A platform for analyzing microarray datasets that incorporate replicate measures
Background: The incorporation of statistical models that account for experimental variability provides a necessary framework for the interpretation of microarray data. A robust ex...
Kevin A. Greer, Matthew R. McReynolds, Heddwen L. ...
BMCBI
2006
107views more  BMCBI 2006»
15 years 6 months ago
Evaluation of methods for oligonucleotide array data via quantitative real-time PCR
Background: There are currently many different methods for processing and summarizing probelevel data from Affymetrix oligonucleotide arrays. It is of great interest to validate t...
Li-Xuan Qin, Richard P. Beyer, Francesca N. Hudson...
BMCBI
2006
130views more  BMCBI 2006»
15 years 6 months ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...
NAR
2008
113views more  NAR 2008»
15 years 6 months ago
miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes
MicroRNAs (miRNAs) are small non-coding RNA molecules that can negatively regulate gene expression and thus control numerous cellular mechanisms. This work develops a resource, mi...
Sheng-Da Hsu, Chia-Huei Chu, Ann-Ping Tsou, Shu-Je...