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» The effect of sequence quality on sequence alignment
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IPPS
2003
IEEE
14 years 1 months ago
Using Hybrid Alignment for Iterative Sequence Database Searches
Progressive sequence model refinement by means of iterative searches is an effective technique for high sensitivity database searches and is currently employed in popular tools s...
Yuheng Li, Mario Lauria, Ralf Bundschuh
ISMB
1994
13 years 9 months ago
An Efficient Method for Multiple Sequence Alignment
Multiple sequence alignment has been a useful methodin the study of molecular evolution and sequence-structure relationships. This paper presents a newmethodfor multiple sequence ...
Jin Kim, Sakti Pramanik
BMCBI
2004
177views more  BMCBI 2004»
13 years 8 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
BIOCOMP
2007
13 years 10 months ago
Quality-Based Similarity Search for Biological Sequence Databases
Low-Complexity Regions (LCRs) of biological sequences are the main source of false positives in similarity searches for biological sequence databases. We consider the problem of ...
Xuehui Li, Tamer Kahveci
BMCBI
2005
123views more  BMCBI 2005»
13 years 8 months ago
PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability
Background: Protein sequence alignments have become indispensable for virtually any evolutionary, structural or functional study involving proteins. Modern sequence search and com...
Mindaugas Margelevicius, Ceslovas Venclovas