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» The elastic net algorithm and protein structure prediction
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GECCO
2008
Springer
135views Optimization» more  GECCO 2008»
13 years 8 months ago
Evolving sequence patterns for prediction of sub-cellular locations of eukaryotic proteins
A genetic algorithm (GA) is utilised to discover known and novel PROSITE-like sequence templates that can be used to classify the sub-cellular location of eukaryotic proteins. Whi...
Greg Paperin
NIPS
2004
13 years 9 months ago
Identifying Protein-Protein Interaction Sites on a Genome-Wide Scale
Protein interactions typically arise from a physical interaction of one or more small sites on the surface of the two proteins. Identifying these sites is very important for drug ...
Haidong Wang, Eran Segal, Asa Ben-Hur, Daphne Koll...
BMCBI
2010
150views more  BMCBI 2010»
13 years 7 months ago
Automatic structure classification of small proteins using random forest
Background: Random forest, an ensemble based supervised machine learning algorithm, is used to predict the SCOP structural classification for a target structure, based on the simi...
Pooja Jain, Jonathan D. Hirst
BMCBI
2008
175views more  BMCBI 2008»
13 years 7 months ago
Comprehensive inventory of protein complexes in the Protein Data Bank from consistent classification of interfaces
Background: Protein-protein interactions are ubiquitous and essential for all cellular processes. High-resolution X-ray crystallographic structures of protein complexes can reveal...
Andrew J. Bordner, Andrey A. Gorin
IJBRA
2010
134views more  IJBRA 2010»
13 years 6 months ago
Deterministic graph-theoretic algorithm for detecting modules in biological interaction networks
—Accumulating evidence suggests that biological systems exhibit modular organization. Accurate identification of modularity is vital for understanding this organization. A recen...
Roger L. Chang, Feng Luo, Stuart Johnson, Richard ...