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» The evolutionary capacity of protein structures
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CANDC
2006
ACM
13 years 7 months ago
Unraveling the nature of the segmentation clock: Intrinsic disorder of clock proteins and their interaction map
Vertebrate segmentation has been proved to be under a strict temporal control governed by a biological clock, known as the segmentation clock. The present experimental evidence su...
Sourav Roy, Santiago Schnell, Predrag Radivojac
BMCBI
2005
90views more  BMCBI 2005»
13 years 7 months ago
TMB-Hunt: An amino acid composition based method to screen proteomes for beta-barrel transmembrane proteins
Background: Beta-barrel transmembrane (bbtm) proteins are a functionally important and diverse group of proteins expressed in the outer membranes of bacteria (both gram negative a...
Andrew G. Garrow, Alison Agnew, David R. Westhead
BMCBI
2005
123views more  BMCBI 2005»
13 years 7 months ago
PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability
Background: Protein sequence alignments have become indispensable for virtually any evolutionary, structural or functional study involving proteins. Modern sequence search and com...
Mindaugas Margelevicius, Ceslovas Venclovas
BMCBI
2006
85views more  BMCBI 2006»
13 years 7 months ago
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...
Rui Jiang, Hua Yang, Fengzhu Sun, Ting Chen
AAAI
2000
13 years 8 months ago
Applying Learnable Evolution Model to Heat Exchanger Design
A new approach to evolutionary computation, called Learnable Evolution Model (LEM), has been applied to the problem of optimizing tube structures of heat exchangers. In contrast t...
Kenneth A. Kaufman, Ryszard S. Michalski