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BMCBI
2008
135views more  BMCBI 2008»
13 years 7 months ago
Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodies
Background: In the adaptive immune system, variable regions of immunoglobulin (IG) are encoded by random recombination of variable (V), diversity (D), and joining (J) gene segment...
Xiaojing Wang, Di Wu, SiYuan Zheng, Jing Sun, Lin ...
CORR
2008
Springer
76views Education» more  CORR 2008»
13 years 7 months ago
Succinct Geometric Indexes Supporting Point Location Queries
We propose to design data structures called succinct geometric indexes of negligible space (more precisely, o(n) bits) that support geometric queries in optimal time, by taking adv...
Prosenjit Bose, Eric Y. Chen, Meng He, Anil Mahesh...
ALMOB
2006
113views more  ALMOB 2006»
13 years 7 months ago
Inverse bifurcation analysis: application to simple gene systems
Background: Bifurcation analysis has proven to be a powerful method for understanding the qualitative behavior of gene regulatory networks. In addition to the more traditional for...
James Lu, Heinz W. Engl, Peter Schuster
BMCBI
2006
123views more  BMCBI 2006»
13 years 7 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger
BMCBI
2006
100views more  BMCBI 2006»
13 years 7 months ago
Using the nucleotide substitution rate matrix to detect horizontal gene transfer
Background: Horizontal gene transfer (HGT) has allowed bacteria to evolve many new capabilities. Because transferred genes perform many medically important functions, such as conf...
Micah Hamady, M. D. Betterton, Rob Knight