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BIOINFORMATICS
2011
12 years 11 months ago
A method for probing the mutational landscape of amyloid structure
Motivation: Proteins of all kinds can self-assemble into highly ordered β-sheet aggregates known as amyloid fibrils, important both biologically and clinically. However, the spe...
Charles W. O'Donnell, Jérôme Waldisp&...
BMCBI
2011
12 years 11 months ago
A hierarchical Bayesian network approach for linkage disequilibrium modeling and data-dimensionality reduction prior to genome-w
Background: Discovering the genetic basis of common genetic diseases in the human genome represents a public health issue. However, the dimensionality of the genetic data (up to 1...
Raphael Mourad, Christine Sinoquet, Philippe Leray
BMCBI
2011
12 years 11 months ago
Efficient alignment of pyrosequencing reads for re-sequencing applications
Background: Over the past few years, new massively parallel DNA sequencing technologies have emerged. These platforms generate massive amounts of data per run, greatly reducing th...
Francisco Fernandes, Paulo G. S. da Fonseca, Lu&ia...
EDBT
2011
ACM
256views Database» more  EDBT 2011»
12 years 11 months ago
RanKloud: a scalable ranked query processing framework on hadoop
The popularity of batch-oriented cluster architectures like Hadoop is on the rise. These batch-based systems successfully achieve high degrees of scalability by carefully allocati...
K. Selçuk Candan, Parth Nagarkar, Mithila N...
FAST
2011
12 years 11 months ago
Emulating Goliath Storage Systems with David
Benchmarking file and storage systems on large filesystem images is important, but difficult and often infeasible. Typically, running benchmarks on such large disk setups is a ...
Nitin Agrawal, Leo Arulraj, Andrea C. Arpaci-Dusse...