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» Theoretical and Experimental DNA Computation
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BMCBI
2004
96views more  BMCBI 2004»
13 years 6 months ago
Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
Olga V. Matveeva, Brian T. Foley, Vladimir A. Nemt...
JCB
2000
105views more  JCB 2000»
13 years 6 months ago
A Greedy Algorithm for Aligning DNA Sequences
For aligning DNA sequences that differ only by sequencing errors, or by equivalent errors from other sources, a greedy algorithm can be much faster than traditional dynamic progra...
Zheng Zhang 0004, Scott Schwartz, Lukas Wagner, We...
RECOMB
2003
Springer
14 years 7 months ago
Designing seeds for similarity search in genomic DNA
Large-scale comparison of genomic DNA is of fundamental importance in annotating functional elements of genomes. To perform large comparisons efficiently, BLAST (Methods: Companio...
Jeremy Buhler, Uri Keich, Yanni Sun
DNA
2008
Springer
121views Bioinformatics» more  DNA 2008»
13 years 8 months ago
Isothermal Reactivating Whiplash PCR for Locally Programmable Molecular Computation
Whiplash PCR (WPCR), due to Hagiya et al. [1], is a novel technique for autonomous molecular computation where a state machine is implemented with a single stranded DNA molecule a...
John H. Reif, Urmi Majumder
RECOMB
2001
Springer
14 years 7 months ago
A new approach to fragment assembly in DNA sequencing
For the last twenty years fragment assembly in DNA sequencing followed the "overlap - layout - consensus" paradigm that is used in all currently available assembly tools...
Pavel A. Pevzner, Haixu Tang, Michael S. Waterman