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142
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ICDE
2010
IEEE
212views Database» more  ICDE 2010»
15 years 3 months ago
Cleansing uncertain databases leveraging aggregate constraints
— Emerging uncertain database applications often involve the cleansing (conditioning) of uncertain databases using additional information as new evidence for reducing the uncerta...
Haiquan Chen, Wei-Shinn Ku, Haixun Wang
127
Voted
BMCBI
2010
120views more  BMCBI 2010»
15 years 3 months ago
KiDoQ: using docking based energy scores to develop ligand based model for predicting antibacterials
Background: Identification of novel drug targets and their inhibitors is a major challenge in the field of drug designing and development. Diaminopimelic acid (DAP) pathway is a u...
Aarti Garg, Rupinder Tewari, Gajendra P. S. Raghav...
123
Voted
BMCBI
2010
136views more  BMCBI 2010»
15 years 3 months ago
Bias correction and Bayesian analysis of aggregate counts in SAGE libraries
Background: Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation proces...
Russell L. Zaretzki, Michael A. Gilchrist, William...
105
Voted
BMCBI
2010
105views more  BMCBI 2010»
15 years 3 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
134
Voted
BMCBI
2008
155views more  BMCBI 2008»
15 years 3 months ago
Prediction of regulatory elements in mammalian genomes using chromatin signatures
Background: Recent genomic scale survey of epigenetic states in the mammalian genomes has shown that promoters and enhancers are correlated with distinct chromatin signatures, pro...
Kyoung-Jae Won, Iouri Chepelev, Bing Ren, Wei Wang