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BCB
2010
150views Bioinformatics» more  BCB 2010»
13 years 2 months ago
Enzymatic target identification with dynamic states
As a metabolic network reaches from a state to a steady state, a subset of its fluxes gradually change. The sequence of intermediate states, called the dynamic state, shows the pa...
Bin Song, Sanjay Ranka, Tamer Kahveci
BMCBI
2010
102views more  BMCBI 2010»
13 years 2 months ago
Predicting protein-protein interactions in unbalanced data using the primary structure of proteins
Background: Elucidating protein-protein interactions (PPIs) is essential to constructing protein interaction networks and facilitating our understanding of the general principles ...
Chi-Yuan Yu, Lih-Ching Chou, Darby Tien-Hao Chang
BMCBI
2011
13 years 2 months ago
RAIphy: Phylogenetic classification of metagenomics samples using iterative refinement of relative abundance index profiles
Background: Computational analysis of metagenomes requires the taxonomical assignment of the genome contigs assembled from DNA reads of environmental samples. Because of the diver...
Ozkan U. Nalbantoglu, Samuel F. Way, Steven H. Hin...
BMCBI
2011
13 years 2 months ago
Identifying hypermethylated CpG islands using a quantile regression model
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understandin...
Shuying Sun, Zhengyi Chen, Pearlly Yan, Yi-Wen Hua...
BMCBI
2011
13 years 2 months ago
Meta-analysis of gene expression microarrays with missing replicates
Background: Many different microarray experiments are publicly available today. It is natural to ask whether different experiments for the same phenotypic conditions can be combin...
Fan Shi, Gad Abraham, Christopher Leckie, Izhak Ha...