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CORR
2008
Springer
13 years 7 months ago
2008
Springer
This work describes a novel methodology for automatic contour extraction from 2D images of 3D neurons (e.g. camera lucida images and other types of 2D microscopy). Most contour-ba...
BMCBI
2006
13 years 7 months ago
2006
Background: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding ...
BMCBI
2006
13 years 7 months ago
2006
Background: Statistical methods for identifying positively selected sites in protein coding regions are one of the most commonly used tools in evolutionary bioinformatics. However...
BMCBI
2006
2006
A Regression-based K nearest neighbor algorithm for gene function prediction from heterogeneous data
13 years 7 months ago
Background: As a variety of functional genomic and proteomic techniques become available, there is an increasing need for functional analysis methodologies that integrate heteroge...
BMCBI
2006
13 years 7 months ago
2006
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...