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BMCBI
2010
147views more  BMCBI 2010»
13 years 7 months ago
CNstream: A method for the identification and genotyping of copy number polymorphisms using Illumina microarrays
Background: Understanding the genetic basis of disease risk in depth requires an exhaustive knowledge of the types of genetic variation. Very recently, Copy Number Variants (CNVs)...
Arnald Alonso, Antonio Julià, Raül Tor...
BMCBI
2010
156views more  BMCBI 2010»
13 years 7 months ago
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
Background: High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical question...
James H. Bullard, Elizabeth Purdom, Kasper D. Hans...
BMCBI
2010
135views more  BMCBI 2010»
13 years 7 months ago
Detecting disease associated modules and prioritizing active genes based on high throughput data
Background: The accumulation of high-throughput data greatly promotes computational investigation of gene function in the context of complex biological systems. However, a biologi...
Yu-Qing Qiu, Shi-Hua Zhang, Xiang-Sun Zhang, Luona...
BMCBI
2008
133views more  BMCBI 2008»
13 years 7 months ago
ElliPro: a new structure-based tool for the prediction of antibody epitopes
Background: Reliable prediction of antibody, or B-cell, epitopes remains challenging yet highly desirable for the design of vaccines and immunodiagnostics. A correlation between a...
Julia V. Ponomarenko, Huynh-Hoa Bui, Wei Li, Nicho...
BMCBI
2008
128views more  BMCBI 2008»
13 years 7 months ago
Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure
Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...
Christopher Bystroff, Bobbie-Jo M. Webb-Robertson