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» Using Multiple Alignments to Improve Gene Prediction
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BMCBI
2011
12 years 11 months ago
Reconstructing genome-wide regulatory network of E. coli using transcriptome data and predicted transcription factor activities
Background: Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes. Un...
Yao Fu, Laura R. Jarboe, Julie A. Dickerson
NAR
2008
152views more  NAR 2008»
13 years 7 months ago
PROMALS3D web server for accurate multiple protein sequence and structure alignments
Multiple sequence alignments are essential in computational sequence and structural analysis, with applications in homology detection, structure modeling, function prediction and ...
Jimin Pei, Ming Tang, Nick V. Grishin
BMCBI
2006
156views more  BMCBI 2006»
13 years 7 months ago
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models
Background: Horizontal gene transfer (HGT) is considered a strong evolutionary force shaping the content of microbial genomes in a substantial manner. It is the difference in spee...
Stephan Waack, Oliver Keller, Roman Asper, Thomas ...
ICASSP
2010
IEEE
13 years 5 months ago
Multiple sequence alignment based bootstrapping for improved incremental word learning
We investigate incremental word learning with few training examples in a Hidden Markov Model (HMM) framework suitable for an interactive learning scenario with little prior knowle...
Irene Ayllól Clemente, Martin Heckmann, Ger...
BMCBI
2010
125views more  BMCBI 2010»
13 years 7 months ago
Asymmetric microarray data produces gene lists highly predictive of research literature on multiple cancer types
Background: Much of the public access cancer microarray data is asymmetric, belonging to datasets containing no samples from normal tissue. Asymmetric data cannot be used in stand...
Noor B. Dawany, Aydin Tozeren