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» Using Multiple Alignments to Improve Gene Prediction
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106
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ICMLA
2008
15 years 4 months ago
Comprehensible Models for Predicting Molecular Interaction with Heart-Regulating Genes
When using machine learning for in silico modeling, the goal is normally to obtain highly accurate predictive models. Often, however, models should also bring insights into intere...
Cecilia Sönströd, Ulf Johansson, Ulf Nor...
149
Voted
BMCBI
2004
96views more  BMCBI 2004»
15 years 3 months ago
Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
Olga V. Matveeva, Brian T. Foley, Vladimir A. Nemt...
111
Voted
BMCBI
2010
96views more  BMCBI 2010»
15 years 3 months ago
Incorporating gene co-expression network in identification of cancer prognosis markers
Background: Extensive biomedical studies have shown that clinical and environmental risk factors may not have sufficient predictive power for cancer prognosis. The development of ...
Shuangge Ma, Mingyu Shi, Yang Li, Danhui Yi, Ben-C...
119
Voted
BMCBI
2008
138views more  BMCBI 2008»
15 years 3 months ago
Application of nonnegative matrix factorization to improve profile-profile alignment features for fold recognition and remote ho
Background: Nonnegative matrix factorization (NMF) is a feature extraction method that has the property of intuitive part-based representation of the original features. This uniqu...
Inkyung Jung, Jaehyung Lee, Soo-Young Lee, Dongsup...
NAR
1998
76views more  NAR 1998»
15 years 3 months ago
U-insertion/deletion Edited Sequence Database
Uridine insertion/deletion RNA editing is a posttranscriptional RNA modification occurring in the mitochondria of kinetoplastid protozoa. The U-insertion/ deletion Edited Sequence...
Larry Simpson, Shirley H. Wang, Otavio H. Thiemann...