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» Using Multiple Alignments to Improve Gene Prediction
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CSB
2005
IEEE
137views Bioinformatics» more  CSB 2005»
14 years 28 days ago
Improving Operon Prediction in E. coli
In bacterium, genes working in the same pathway or interacting with each other are often organized into operons. Currently, the prediction accuracy for operon/boundary gene pairs ...
PhuongAn Dam, Victor Olman, Ying Xu
BMCBI
2008
145views more  BMCBI 2008»
13 years 7 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BIBM
2008
IEEE
217views Bioinformatics» more  BIBM 2008»
14 years 1 months ago
Combining Hierarchical Inference in Ontologies with Heterogeneous Data Sources Improves Gene Function Prediction
The study of gene function is critical in various genomic and proteomic fields. Due to the availability of tremendous amounts of different types of protein data, integrating thes...
Xiaoyu Jiang, Naoki Nariai, Martin Steffen, Simon ...
BMCBI
2008
244views more  BMCBI 2008»
13 years 7 months ago
RNAalifold: improved consensus structure prediction for RNA alignments
Background: The prediction of a consensus structure for a set of related RNAs is an important first step for subsequent analyses. RNAalifold, which computes the minimum energy str...
Stephan H. F. Bernhart, Ivo L. Hofacker, Sebastian...
BMCBI
2006
117views more  BMCBI 2006»
13 years 7 months ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala