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» Using PQ Trees for Comparative Genomics
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GECCO
2005
Springer
162views Optimization» more  GECCO 2005»
14 years 1 months ago
Discovering biological motifs with genetic programming
Choosing the right representation for a problem is important. In this article we introduce a linear genetic programming approach for motif discovery in protein families, and we al...
Rolv Seehuus, Amund Tveit, Ole Edsberg
BMCBI
2004
126views more  BMCBI 2004»
13 years 7 months ago
A probabilistic model for the evolution of RNA structure
Background: For the purposes of finding and aligning noncoding RNA gene- and cis-regulatory elements in multiple-genome datasets, it is useful to be able to derive multi-sequence ...
Ian Holmes
BMCBI
2008
200views more  BMCBI 2008»
13 years 7 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
BMCBI
2007
106views more  BMCBI 2007»
13 years 7 months ago
Constructing a meaningful evolutionary average at the phylogenetic center of mass
Background: As a consequence of the evolutionary process, data collected from related species tend to be similar. This similarity by descent can obscure subtler signals in the dat...
Eric A. Stone, Arend Sidow
IJIT
2004
13 years 9 months ago
Computing Entropy for Ortholog Detection
Abstract-- Biological sequences from different species are called orthologs if they evolved from a sequence of a common ancestor species and they have the same biological function....
Hsing-Kuo Pao, John Case