- The search for structural similarity among proteins can provide valuable insights into their functional mechanisms and their functional relationships. Though the protein 1D seque...
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
Gene functions is an essential knowledge for understanding how metabolism works and designing treatments for solving malfunctions. The Modular Multi-Relational Framework (MMRF) is ...
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
The Hierarchical Mixture of Experts (HME) is a well-known tree-structured model for regression and classification, based on soft probabilistic splits of the input space. In its o...