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BIOCOMP
2006
13 years 9 months ago
A Multi-strategy Approach to Protein Structural Alphabet Design
- The search for structural similarity among proteins can provide valuable insights into their functional mechanisms and their functional relationships. Though the protein 1D seque...
Shih-Yen Ku, Yuh-Jyh Hu
BMCBI
2008
200views more  BMCBI 2008»
13 years 7 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
IEAAIE
2010
Springer
13 years 5 months ago
S.cerevisiae Complex Function Prediction with Modular Multi-Relational Framework
Gene functions is an essential knowledge for understanding how metabolism works and designing treatments for solving malfunctions. The Modular Multi-Relational Framework (MMRF) is ...
Beatriz García Jiménez, Agapito Lede...
BMCBI
2006
120views more  BMCBI 2006»
13 years 7 months ago
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding prote
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
Michael E. Bradley, Steven A. Benner
UAI
2003
13 years 9 months ago
Bayesian Hierarchical Mixtures of Experts
The Hierarchical Mixture of Experts (HME) is a well-known tree-structured model for regression and classification, based on soft probabilistic splits of the input space. In its o...
Christopher M. Bishop, Markus Svensén