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JNS
2008
79views more  JNS 2008»
13 years 7 months ago
Singularly Perturbed Monotone Systems and an Application to Double Phosphorylation Cycles
The theory of monotone dynamical systems has been found very useful in the modeling of some gene, protein, and signaling networks. In monotone systems, every net feedback loop is p...
Liming Wang, Eduardo D. Sontag
SODA
2010
ACM
155views Algorithms» more  SODA 2010»
14 years 4 months ago
Road Network Reconstruction for Organizing Paths
We consider the problem of reconstructing a road network from a collection of path traces and provide guarantees on the accuracy of the reconstruction under reasonable assumptions...
Daniel Chen, Leonidas J. Guibas, John Hershberger,...
BMCBI
2008
146views more  BMCBI 2008»
13 years 7 months ago
Rank-based edge reconstruction for scale-free genetic regulatory networks
Background: The reconstruction of genetic regulatory networks from microarray gene expression data has been a challenging task in bioinformatics. Various approaches to this proble...
Guanrao Chen, Peter Larsen, Eyad Almasri, Yang Dai
BMCBI
2010
114views more  BMCBI 2010»
13 years 7 months ago
Detection of gene orthology from gene co-expression and protein interaction networks
Background: Ortholog detection methods present a powerful approach for finding genes that participate in similar biological processes across different organisms, extending our und...
Fadi Towfic, Susan VanderPlas, Casey A. Oliver, Ol...
CSB
2003
IEEE
130views Bioinformatics» more  CSB 2003»
14 years 20 days ago
A Computational Approach to Reconstructing Gene Regulatory Networks
Reverse-engineering of gene networks using linear models often results in an underdetermined system because of excessive unknown parameters. In addition, the practical utility of ...
Xutao Deng, Hesham H. Ali