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BMCBI
2004
144views more  BMCBI 2004»
13 years 7 months ago
GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes
Background: The function of a novel gene product is typically predicted by transitive assignment of annotation from similar sequences. We describe a novel method, GOtcha, for pred...
David M. A. Martin, Matthew Berriman, Geoffrey J. ...
CSB
2005
IEEE
223views Bioinformatics» more  CSB 2005»
14 years 29 days ago
Automatic Protein Function Annotation through Candidate Ortholog Clusters from Incomplete Genomes
Annotation of protein function often arises in the context of partially complete genomes but is not adequately addressed. We present an annotation method by extracting ortholog cl...
Akshay Vashist, Casimir A. Kulikowski, Ilya B. Muc...
BMCBI
2005
131views more  BMCBI 2005»
13 years 7 months ago
Functional annotation by identification of local surface similarities: a novel tool for structural genomics
Background: Protein function is often dependent on subsets of solvent-exposed residues that may exist in a similar three-dimensional configuration in non homologous proteins thus ...
Fabrizio Ferrè, Gabriele Ausiello, Andreas ...
BMCBI
2005
173views more  BMCBI 2005»
13 years 7 months ago
Phydbac "Gene Function Predictor" : a gene annotation tool based on genomic context analysis
Background: The large amount of completely sequenced genomes allows genomic context analysis to predict reliable functional associations between prokaryotic proteins. Major method...
François Enault, Karsten Suhre, Jean-Michel...
BMCBI
2006
165views more  BMCBI 2006»
13 years 7 months ago
Validation and functional annotation of expression-based clusters based on gene ontology
Background: The biological interpretation of large-scale gene expression data is one of the paramount challenges in current bioinformatics. In particular, placing the results in t...
Ralf Steuer, Peter Humburg, Joachim Selbig