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BIOINFORMATICS
2006
124views more  BIOINFORMATICS 2006»
13 years 9 months ago
Probabilistic inference of transcription factor concentrations and gene-specific regulatory activities
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
Guido Sanguinetti, Neil D. Lawrence, Magnus Rattra...
BIOINFORMATICS
2005
110views more  BIOINFORMATICS 2005»
13 years 9 months ago
Classification of oligonucleotide fingerprints: application for microbial community and gene expression analyses
Oligonucleotide fingerprinting is an array-based approach used for analysis of microbial community composition and gene expression profiling. Oligonucleotide fingerprinting of rib...
Katechan Jampachaisri, Lea Valinsky, James Bornema...
BIOINFORMATICS
2005
93views more  BIOINFORMATICS 2005»
13 years 9 months ago
Donuts, scratches and blanks: robust model-based segmentation of microarray images
Inner holes, artifacts and blank spots are common in microarray images, but current image analysis methods do not pay them enough attention. We propose a new robust model-based me...
Qunhua Li, Chris Fraley, Roger Eugene Bumgarner, K...
BIOINFORMATICS
2005
152views more  BIOINFORMATICS 2005»
13 years 9 months ago
Intervention in context-sensitive probabilistic Boolean networks
Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been...
Ranadip Pal, Aniruddha Datta, Michael L. Bittner, ...
BIOINFORMATICS
2005
72views more  BIOINFORMATICS 2005»
13 years 9 months ago
Use of within-array replicate spots for assessing differential expression in microarray experiments
Motivation. Spotted arrays are often printed with probes in duplicate or triplicate, but current methods for assessing differential expression are not able to make full use of the...
Gordon K. Smyth, Joëlle Michaud, Hamish S. Sc...