When aligning biological sequences, the choice of parameter values for the alignment scoring function is critical. Small changes in gap penalties, for example, can yield radically ...
Abstract. Parameter estimation of large bio-pathway models is an important and difficult problem. To reduce the prohibitive computational cost, one approach is to decompose a large...
Geoffrey Koh, Lisa Tucker-Kellogg, David Hsu, P. S...
We introduce a mixture of probabilistic canonical correlation analyzers model for analyzing local correlations, or more generally mutual statistical dependencies, in cooccurring d...
Following the agile philosophy that all core features of a system need an automated test harness, performance requirements also need such a check when they are essential for the s...
1 Profile Hidden Markov Models (profile HMMs) are used as a popular bioinformatics tool for sensitive database searching, e.g. a set of not annotated protein sequences is compared...