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BMCBI
2008
190views more  BMCBI 2008»
13 years 8 months ago
Which missing value imputation method to use in expression profiles: a comparative study and two selection schemes
Background: Gene expression data frequently contain missing values, however, most downstream analyses for microarray experiments require complete data. In the literature many meth...
Guy N. Brock, John R. Shaffer, Richard E. Blakesle...
BMCBI
2008
73views more  BMCBI 2008»
13 years 8 months ago
Parallel and serial computing tools for testing single-locus and epistatic SNP effects of quantitative traits in genome-wide ass
Background: Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers provide opportunities to detect epistatic SNPs associated with quantitative t...
Li Ma, H. Birali Runesha, Daniel Dvorkin, John R. ...
BMCBI
2008
87views more  BMCBI 2008»
13 years 8 months ago
Evaluation of two methods for computational HLA haplotypes inference using a real dataset
Background: HLA haplotype analysis has been used in population genetics and in the investigation of disease-susceptibility locus, due to its high polymorphism. Several methods for...
Bruno F. Bettencourt, Margarida R. Santos, Raquel ...
BMCBI
2008
134views more  BMCBI 2008»
13 years 8 months ago
PEPOP: Computational design of immunogenic peptides
Background: Most methods available to predict protein epitopes are sequence based. There is a need for methods using 3D information for prediction of discontinuous epitopes and de...
Violaine Moreau, Cécile Fleury, Dominique P...
BMCBI
2008
106views more  BMCBI 2008»
13 years 8 months ago
Integrating biological data - the Distributed Annotation System
Background: The Distributed Annotation System (DAS) is a widely adopted protocol for dynamically integrating a wide range of biological data from geographically diverse sources. D...
Andrew M. Jenkinson, Mario Albrecht, Ewan Birney, ...