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BMCBI
2008
13 years 9 months ago
2008
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
BMCBI
2008
13 years 9 months ago
2008
Background: Modern sequencing technologies allow rapid sequencing and bioinformatic analysis of genomes and metagenomes. With every new sequencing project a vast number of new pro...
BMCBI
2008
13 years 9 months ago
2008
Background: The discovery of biomarkers is an important step towards the development of criteria for early diagnosis of disease status. Recently electrospray ionization (ESI) and ...
BMCBI
2008
13 years 9 months ago
2008
Background: The models developed to characterize the evolution of multigene families (such as the birth-and-death and the concerted models) have also been applied on the level of ...
BMCBI
2008
13 years 9 months ago
2008
Background: The identification and characterization of interacting domain pairs is an important step towards understanding protein interactions. In the last few years, several met...