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BMCBI
2011
13 years 4 months ago
Investigating the effect of paralogs on microarray gene-set analysis
Background: In order to interpret the results obtained from a microarray experiment, researchers often shift focus from analysis of individual differentially expressed genes to an...
Andre J. Faure, Cathal Seoighe, Nicola J. Mulder
BMCBI
2011
13 years 4 months ago
Systematic error detection in experimental high-throughput screening
Background: High-throughput screening (HTS) is a key part of the drug discovery process during which thousands of chemical compounds are screened and their activity levels measure...
Plamen Dragiev, Robert Nadon, Vladimir Makarenkov
BMCBI
2011
13 years 4 months ago
Tiling array data analysis: a multiscale approach using wavelets
Background: Tiling array data is hard to interpret due to noise. The wavelet transformation is a widely used technique in signal processing for elucidating the true signal from no...
Alexander Karpikov, Joel S. Rozowsky, Mark Gerstei...
BMCBI
2011
13 years 4 months ago
PhyloSim - Monte Carlo simulation of sequence evolution in the R statistical computing environment
Background: The Monte Carlo simulation of sequence evolution is routinely used to assess the performance of phylogenetic inference methods and sequence alignment algorithms. Progr...
Botond Sipos, Tim Massingham, Gregory E. Jordan, N...
BMCBI
2011
13 years 1 months ago
The Biomedical Discourse Relation Bank
Background: Identification of discourse relations, such as causal and contrastive relations, between situations mentioned in text is an important task for biomedical text-mining. ...
Rashmi Prasad, Susan McRoy, Nadya Frid, Aravind K....