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BMCBI
2011
13 years 1 months ago
Smith-Waterman Peak Alignment for Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry
Background: Comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC × GCMS) is a powerful technique which has gained increasing attention over the las...
Seongho Kim, Imhoi Koo, Aiqin Fang, Xiang Zhang
BMCBI
2011
13 years 1 months ago
Cell Subset Prediction for Blood Genomic Studies
Background: Genome-wide transcriptional profiling of patient blood samples offers a powerful tool to investigate underlying disease mechanisms and personalized treatment decisions...
Christopher R. Bolen, Mohamed Uduman, Steven H. Kl...
BMCBI
2011
13 years 1 months ago
A mutation degree model for the identification of transcriptional regulatory elements
Background: Current approaches for identifying transcriptional regulatory elements are mainly via the combination of two properties, the evolutionary conservation and the overrepr...
Changqing Zhang, Jin Wang, Xu Hua, Jinggui Fang, H...
BMCBI
2011
13 years 4 months ago
RAIphy: Phylogenetic classification of metagenomics samples using iterative refinement of relative abundance index profiles
Background: Computational analysis of metagenomes requires the taxonomical assignment of the genome contigs assembled from DNA reads of environmental samples. Because of the diver...
Ozkan U. Nalbantoglu, Samuel F. Way, Steven H. Hin...
BMCBI
2011
13 years 4 months ago
A theoretical entropy score as a single value to express inhibitor selectivity
Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
Joost C. M. Uitdehaag, Guido J. R. Zaman