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BMCBI
2011
13 years 1 months ago
Combinatorial analysis and algorithms for quasispecies reconstruction using next-generation sequencing
Background: Next-generation sequencing (NGS) offers a unique opportunity for high-throughput genomics and has potential to replace Sanger sequencing in many fields, including de-n...
Mattia C. F. Prosperi, Luciano Prosperi, Alessandr...
BMCBI
2011
13 years 1 months ago
CLOTU: An online pipeline for processing and clustering of 454 amplicon reads into OTUs followed by taxonomic annotation
Background: The implementation of high throughput sequencing for exploring biodiversity poses high demands on bioinformatics applications for automated data processing. Here we in...
Surendra Kumar, Tor Carlsen, Bjørn-Helge Me...
BMCBI
2011
13 years 1 months ago
Detection of recurrent rearrangement breakpoints from copy number data
Background: Copy number variants (CNVs), including deletions, amplifications, and other rearrangements, are common in human and cancer genomes. Copy number data from array compara...
Anna M. Ritz, Pamela L. Paris, Michael Ittmann, Co...
BMCBI
2011
13 years 1 months ago
BICEPP: an example-based statistical text mining method for predicting the binary characteristics of drugs
Background: The identification of drug characteristics is a clinically important task, but it requires much expert knowledge and consumes substantial resources. We have developed ...
Frank P. Y. Lin, Stephen Anthony, Thomas M. Polase...
BMCBI
2011
13 years 1 months ago
The Proteogenomic Mapping Tool
Background: High-throughput mass spectrometry (MS) proteomics data is increasingly being used to complement traditional structural genome annotation methods. To keep pace with the...
William S. Sanders, Nan Wang, Susan M. Bridges, Br...