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BMCBI
2011
13 years 4 months ago
DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning
Background: Accurate identification of protein domain boundaries is useful for protein structure determination and prediction. However, predicting protein domain boundaries from a...
Jesse Eickholt, Xin Deng, Jianlin Cheng
BMCBI
2011
13 years 4 months ago
A lightweight, flow-based toolkit for parallel and distributed bioinformatics pipelines
Background: Bioinformatic analyses typically proceed as chains of data-processing tasks. A pipeline, or ‘workflow’, is a well-defined protocol, with a specific structure defin...
Marcin Cieslik, Cameron Mura
BMCBI
2011
13 years 4 months ago
Empirical Bayesian models for analysing molecular serotyping microarrays
Background: Microarrays offer great potential as a platform for molecular diagnostics, testing clinical samples for the presence of numerous biomarkers in highly multiplexed assay...
Richard Newton, Jason Hinds, Lorenz Wernisch
BMCBI
2011
13 years 4 months ago
Errors in CGAP xProfiler and cDNA DGED: the importance of library parsing and gene selection algorithms
Background: The Cancer Genome Anatomy Project (CGAP) xProfiler and cDNA Digital Gene Expression Displayer (DGED) have been made available to the scientific community over a decade...
Andrew T. Milnthorpe, Mikhail Soloviev
BMCBI
2011
13 years 4 months ago
Properties of Metabolic Graphs: Biological Organization or Representation Artifacts?
Background: Standard graphs, where each edge links two nodes, have been extensively used to represent the connectivity of metabolic networks. It is based on this representation th...
Wanding Zhou, Luay Nakhleh