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134
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BMCBI
2006
15 years 3 months ago
2006
Background: Hidden Markov Models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. In many applications, such...
149
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BMCBI
2006
15 years 3 months ago
2006
Background: The extended use of microarray technologies has enabled the generation and accumulation of gene expression datasets that contain expression levels of thousands of gene...
117
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BMCBI
2006
15 years 3 months ago
2006
Background: Unigenic evolution is a powerful genetic strategy involving random mutagenesis of a single gene product to delineate functionally important domains of a protein. This ...
132
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BMCBI
2006
15 years 3 months ago
2006
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...
110
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BMCBI
2006
15 years 3 months ago
2006
Background: Determining whether a gene is differentially expressed in two different samples remains an important statistical problem. Prior work in this area has featured the use ...