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ANOR
2010
123views more  ANOR 2010»
13 years 10 months ago
Nature inspired genetic algorithms for hard packing problems
This paper presents two novel genetic algorithms (GAs) for hard industrially relevant packing problems. The design of both algorithms is inspired by aspects of molecular genetics,...
Philipp Rohlfshagen, John A. Bullinaria
BIOINFORMATICS
2010
94views more  BIOINFORMATICS 2010»
13 years 10 months ago
Globally, unrelated protein sequences appear random
Motivation: To test whether protein folding constraints and secondary structure sequence preferences significantly reduce the space of amino acid words in proteins, we compared th...
Daniel T. Lavelle, William R. Pearson
BMCBI
2010
62views more  BMCBI 2010»
13 years 10 months ago
Forward-time simulation of realistic samples for genome-wide association studies
Background: Forward-time simulations have unique advantages in power and flexibility for the simulation of genetic samples of complex human diseases because they can closely mimic...
Bo Peng, Christopher I. Amos
BMCBI
2010
116views more  BMCBI 2010»
13 years 10 months ago
Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences
Background: Precise and efficient methods for gene targeting are critical for detailed functional analysis of genomes and regulatory networks and for potentially improving the eff...
Jeffry D. Sander, Deepak Reyon, Morgan L. Maeder, ...
CCR
2010
131views more  CCR 2010»
13 years 10 months ago
DECOR: DEClarative network management and OpeRation
Network management operations are complicated, tedious and error-prone, requiring significant human involvement and expert knowledge. In this paper, we first examine the fundament...
Xu Chen, Yun Mao, Zhuoqing Morley Mao, Jacobus E. ...