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BMCBI
2005
149views more  BMCBI 2005»
13 years 8 months ago
The PD-(D/E)XK superfamily revisited: identification of new members among proteins involved in DNA metabolism and functional pre
Background: The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is o...
Jan Kosinski, Marcin Feder, Janusz M. Bujnicki
BMCBI
2005
122views more  BMCBI 2005»
13 years 8 months ago
Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein
Background: Recognition codes for protein-DNA interactions typically assume that the interacting positions contribute additively to the binding energy. While this is known to not ...
Jiajian Liu, Gary D. Stormo
BMCBI
2005
131views more  BMCBI 2005»
13 years 8 months ago
Regularized Least Squares Cancer Classifiers from DNA microarray data
Background: The advent of the technology of DNA microarrays constitutes an epochal change in the classification and discovery of different types of cancer because the information ...
Nicola Ancona, Rosalia Maglietta, Annarita D'Addab...
BMCBI
2005
82views more  BMCBI 2005»
13 years 8 months ago
A novel method for prokaryotic promoter prediction based on DNA stability
Background: In the post-genomic era, correct gene prediction has become one of the biggest challenges in genome annotation. Improved promoter prediction methods can be one step to...
Aditi Kanhere, Manju Bansal
BMCBI
2005
114views more  BMCBI 2005»
13 years 8 months ago
Extension of Lander-Waterman theory for sequencing filtered DNA libraries
Background: The degree to which conventional DNA sequencing techniques will be successful for highly repetitive genomes is unclear. Investigators are therefore considering various...
Michael C. Wendl, W. Bradley Barbazuk