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BMCBI
2006
13 years 8 months ago
2006
Background: Various experimental techniques yield peptides that are biologically active but have unfavourable pharmacological properties. The design of structurally similar organi...
BMCBI
2006
13 years 8 months ago
2006
Background: The elucidation of whole-cell regulatory, metabolic, interaction and other biological networks generates the need for a meaningful ranking of network elements. Central...
BMCBI
2006
13 years 8 months ago
2006
Background: The neighbor-joining method by Saitou and Nei is a widely used method for constructing phylogenetic trees. The formulation of the method gives rise to a canonical (n3)...
BMCBI
2006
13 years 8 months ago
2006
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
BMCBI
2006
13 years 8 months ago
2006
Background: Both direct and indirect interactions determine molecular recognition of ligands by proteins. Indirect interactions can be defined as effects on recognition controlled...