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138
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BMCBI
2006
115views more  BMCBI 2006»
15 years 3 months ago
Multivariate curve resolution of time course microarray data
Background: Modeling of gene expression data from time course experiments often involves the use of linear models such as those obtained from principal component analysis (PCA), i...
Peter D. Wentzell, Tobias K. Karakach, Sushmita Ro...
141
Voted
BMCBI
2006
127views more  BMCBI 2006»
15 years 3 months ago
Construction of phylogenetic trees by kernel-based comparative analysis of metabolic networks
Background: To infer the tree of life requires knowledge of the common characteristics of each species descended from a common ancestor as the measuring criteria and a method to c...
Sok June Oh, Je-Gun Joung, Jeong Ho Chang, Byoung-...
128
Voted
BMCBI
2006
92views more  BMCBI 2006»
15 years 3 months ago
Demonstration of two novel methods for predicting functional siRNA efficiency
Background: siRNAs are small RNAs that serve as sequence determinants during the gene silencing process called RNA interference (RNAi). It is well know that siRNA efficiency is cr...
Peilin Jia, Tieliu Shi, Yu-Dong Cai, Yixue Li
167
Voted
BMCBI
2006
161views more  BMCBI 2006»
15 years 3 months ago
A method for rapid similarity analysis of RNA secondary structures
Background: Owing to the rapid expansion of RNA structure databases in recent years, efficient methods for structure comparison are in demand for function prediction and evolution...
Na Liu, Tianming Wang
153
Voted
BMCBI
2006
114views more  BMCBI 2006»
15 years 3 months ago
PROMPT: a protein mapping and comparison tool
Background: Comparison of large protein datasets has become a standard task in bioinformatics. Typically researchers wish to know whether one group of proteins is significantly en...
Thorsten Schmidt, Dmitrij Frishman
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