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BMCBI
2006
13 years 8 months ago
2006
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
BMCBI
2006
13 years 8 months ago
2006
Background: The identification of a consensus RNA motif often consists in finding a conserved secondary structure with minimum free energy in an ensemble of aligned sequences. How...
BMCBI
2006
13 years 8 months ago
2006
Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
BMCBI
2006
13 years 8 months ago
2006
Background: The imprint of natural selection on gene sequences is often difficult to detect. A plethora of methods have been devised to detect genetic changes due to selective pro...
BMCBI
2006
13 years 8 months ago
2006
Background: Biochemically detailed stoichiometric matrices have now been reconstructed for various bacteria, yeast, and for the human cardiac mitochondrion based on genomic and pr...