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140
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BMCBI
2008
15 years 4 months ago
2008
Background: The traditional (unweighted) k-means is one of the most popular clustering methods for analyzing gene expression data. However, it suffers three major shortcomings. It...
125
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BMCBI
2008
15 years 4 months ago
2008
Background: The methodologies we use both enable and help define our research. However, as experimental complexity has increased the choice of appropriate methodologies has become...
130
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BMCBI
2008
15 years 4 months ago
2008
Background: Population structure analysis is important to genetic association studies and evolutionary investigations. Parametric approaches, e.g. STRUCTURE and L-POP, usually ass...
154
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BMCBI
2008
15 years 4 months ago
2008
Background: Protein secondary structure prediction method based on probabilistic models such as hidden Markov model (HMM) appeals to many because it provides meaningful informatio...
145
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BMCBI
2008
15 years 4 months ago
2008
Background: In gene expression analysis, statistical tests for differential gene expression provide lists of candidate genes having, individually, a sufficiently low p-value. Howe...