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BMCBI
2005
118views more  BMCBI 2005»
13 years 10 months ago
Variation in structural location and amino acid conservation of functional sites in protein domain families
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
Birgit Pils, Richard R. Copley, Jörg Schultz
BMCBI
2005
98views more  BMCBI 2005»
13 years 10 months ago
The effects of normalization on the correlation structure of microarray data
Background: Stochastic dependence between gene expression levels in microarray data is of critical importance for the methods of statistical inference that resort to pooling test-...
Xing Qiu, Andrew I. Brooks, Lev Klebanov, Andrei Y...
BMCBI
2005
75views more  BMCBI 2005»
13 years 10 months ago
Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes
Background: The 'lid' subcomplex of the 26S proteasome and the COP9 signalosome (CSN complex) share a common architecture consisting of six subunits harbouring a so-call...
Hartmut Scheel, Kay Hofmann
BMCBI
2005
97views more  BMCBI 2005»
13 years 10 months ago
Modelling the correlation between the activities of adjacent genes in drosophila
Background: Correlation between the expression levels of genes which are located close to each other on the genome has been found in various organisms, including yeast, drosophila...
Helene H. Thygesen, Aeilko H. Zwinderman
BMCBI
2005
159views more  BMCBI 2005»
13 years 10 months ago
Columba: an integrated database of proteins, structures, and annotations
Background: Structural and functional research often requires the computation of sets of protein structures based on certain properties of the proteins, such as sequence features,...
Silke Trißl, Kristian Rother, Heiko Mül...