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BMCBI
2006
140views more  BMCBI 2006»
13 years 8 months ago
SNP-PHAGE - High throughput SNP discovery pipeline
Background: Single nucleotide polymorphisms (SNPs) as defined here are single base sequence changes or short insertion/deletions between or within individuals of a given species. ...
Lakshmi K. Matukumalli, John J. Grefenstette, Davi...
BMCBI
2006
98views more  BMCBI 2006»
13 years 8 months ago
Optimised amino acid specific weighting factors for unbound protein docking
Background: One of the most challenging aspects of protein-protein docking is the inclusion of flexibility into the docking procedure. We developed a postfilter where the grid-rep...
Philipp Heuser, Dietmar Schomburg
BMCBI
2006
144views more  BMCBI 2006»
13 years 8 months ago
methBLAST and methPrimerDB: web-tools for PCR based methylation analysis
Background: DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methy...
Filip Pattyn, Jasmien Hoebeeck, Piet Robbrecht, Ev...
BMCBI
2006
132views more  BMCBI 2006»
13 years 8 months ago
Genome-wide DNA polymorphism analyses using VariScan
Background: DNA sequence polymorphisms analysis can provide valuable information on the evolutionary forces shaping nucleotide variation, and provides an insight into the function...
Stephan Hutter, Albert J. Vilella, Julio Rozas
BMCBI
2006
116views more  BMCBI 2006»
13 years 8 months ago
MICA: desktop software for comprehensive searching of DNA databases
Background: Molecular biologists work with DNA databases that often include entire genomes. A common requirement is to search a DNA database to find exact matches for a nondegener...
William A. Stokes, Benjamin S. Glick