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BMCBI
2006
113views more  BMCBI 2006»
13 years 11 months ago
In silico discovery of human natural antisense transcripts
Background: Several high-throughput searches for ppotential natural antisense transcripts (NATs) have been performed recently, but most of the reports were focused on cis type. A ...
Yuan-Yuan Li, Lei Qin, Zong-Ming Guo, Lei Liu, Hao...
BMCBI
2006
134views more  BMCBI 2006»
13 years 11 months ago
Application of machine learning in SNP discovery
Background: Single nucleotide polymorphisms (SNP) constitute more than 90% of the genetic variation, and hence can account for most trait differences among individuals in a given ...
Lakshmi K. Matukumalli, John J. Grefenstette, Davi...
BMCBI
2006
123views more  BMCBI 2006»
13 years 11 months ago
How to decide? Different methods of calculating gene expression from short oligonucleotide array data will give different result
Background: Short oligonucleotide arrays for transcript profiling have been available for several years. Generally, raw data from these arrays are analysed with the aid of the Mic...
Frank F. Millenaar, John Okyere, Sean T. May, Mart...
BMCBI
2006
181views more  BMCBI 2006»
13 years 11 months ago
The comprehensive updated regulatory network of Escherichia coli K-12
Background: Escherichia coli is the model organism for which our knowledge of its regulatory network is the most extensive. Over the last few years, our project has been collectin...
Heladia Salgado, Alberto Santos-Zavaleta, Socorro ...
BMCBI
2006
123views more  BMCBI 2006»
13 years 11 months ago
Computational models with thermodynamic and composition features improve siRNA design
Background: Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large fun...
Svetlana A. Shabalina, Alexey N. Spiridonov, Aleks...
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