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JIB
2006
67views more  JIB 2006»
13 years 10 months ago
The implications for Bioinformatics of integration across physical scales
Bioinformatics blossomed with research developments in molecular biology. But as the focus of research moves back up the physical scale to the biology of whole multicellular organ...
T. Charles Hodgman, Y. Ugartechea-Chirino, G. Tans...
JIB
2006
110views more  JIB 2006»
13 years 10 months ago
Combining biomedical knowledge and transcriptomic data to extract new knowledge on genes
In biomedical research, interpretation of microarray data requires confrontation of data and knowledge from heterogeneous resources, either in the biomedical domain or in genomics...
Emilie Guérin, Gwenaëlle Marquet, Juli...
JIB
2006
78views more  JIB 2006»
13 years 10 months ago
Identification of embryo specific human isoforms using a database of predicted alternative splice forms
Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from a small number of genes. Its study became one of the hot ...
Heike Pospisil
JIB
2006
78views more  JIB 2006»
13 years 10 months ago
Prediction of transcription factor binding to DNA using rule induction methods
In this study, we seek to develop a predictive model for finding the strength of binding between a particular transcription factor (TF) variant and a particular DNA target variant...
Mikael Huss, Karin Nordström
JIB
2006
106views more  JIB 2006»
13 years 10 months ago
A structural keystone for drug design
3D-structures of proteins and potential ligands are the cornerstones of rational drug design. The first brick to build upon is selecting a protein target and finding out whether b...
Kristian Rother, Mathias Dunkel, Elke Michalsky, S...