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BMCBI
2006
13 years 9 months ago
2006
Background: Understanding gene regulatory networks has become one of the central research problems in bioinformatics. More than thirty algorithms have been proposed to identify DN...
BMCBI
2006
13 years 9 months ago
2006
Background: Molecular biologists work with DNA databases that often include entire genomes. A common requirement is to search a DNA database to find exact matches for a nondegener...
BMCBI
2006
13 years 9 months ago
2006
Background: Assessment of array quality is an essential step in the analysis of data from microarray experiments. Once detected, less reliable arrays are typically excluded or &qu...
BMCBI
2006
13 years 9 months ago
2006
Background: Recent analyses in systems biology pursue the discovery of functional modules within the cell. Recognition of such modules requires the integrative analysis of genome-...
BMCBI
2006
13 years 9 months ago
2006
Background: A transcriptional regulatory module (TRM) is a set of genes that is regulated by a common set of transcription factors (TFs). By organizing the genome into TRMs, a liv...