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BMCBI
2005
100views more  BMCBI 2005»
15 years 4 months ago
Speeding disease gene discovery by sequence based candidate prioritization
Background: Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is...
Euan A. Adie, Richard R. Adams, Kathryn L. Evans, ...
BMCBI
2005
85views more  BMCBI 2005»
15 years 4 months ago
Prediction of twin-arginine signal peptides
Background: Proteins carrying twin-arginine (Tat) signal peptides are exported into the periplasmic compartment or extracellular environment independently of the classical Secdepe...
Jannick Dyrløv Bendtsen, Henrik Nielsen, Da...
BMCBI
2005
152views more  BMCBI 2005»
15 years 4 months ago
CoPub Mapper: mining MEDLINE based on search term co-publication
Background: High throughput microarray analyses result in many differentially expressed genes that are potentially responsible for the biological process of interest. In order to ...
Blaise T. F. Alako, Antoine Veldhoven, Sjozef van ...
BMCBI
2005
106views more  BMCBI 2005»
15 years 4 months ago
A multistep bioinformatic approach detects putative regulatory elements in gene promoters
Background: Searching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge ...
Stefania Bortoluzzi, Alessandro Coppe, Andrea Biso...
BMCBI
2005
189views more  BMCBI 2005»
15 years 4 months ago
Quantitative inference of dynamic regulatory pathways via microarray data
Background: The cellular signaling pathway (network) is one of the main topics of organismic investigations. The intracellular interactions between genes in a signaling pathway ar...
Wen-Chieh Chang, Chang-Wei Li, Bor-Sen Chen