A current high-priority phase of human genomics involves the development of a full Haplotype Map of the human genome [23]. It will be used in large-scale screens of populations to...
We develop techniques to estimate the statistical significance of gap-free alignments between two genomic DNA sequences, using human-mouse alignments as an example. The sequences ...
One key element in understanding the molecular machinery of the cell is to understand the meaning, or function, of each protein encoded in the genome. A very successful means of i...
The field of algorithms for pairwisc biosequence similarity search is dominated by heuristic methods of high efficiency but uncertain sensitivity. One reason that more formal stri...
We present an original approach to identifying sequence variants in a mixed DNA population from sequence trace data. The heart of the method is based on parsimony: given a wildtyp...