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RECOMB
2008
Springer
14 years 8 months ago
On Computing the Breakpoint Reuse Rate in Rearrangement Scenarios
In the past years, many combinatorial arguments have been made to support the theory that mammalian genome rearrangement scenarios rely heavily on breakpoint reuse. Different model...
Anne Bergeron, Julia Mixtacki, Jens Stoye
RECOMB
2008
Springer
14 years 8 months ago
Ancestral Reconstruction by Asymmetric Wagner Parsimony over Continuous Characters and Squared Parsimony over Distributions
Abstract. Contemporary inferences about evolution occasionally involve analyzing infinitely large feature spaces, requiring specific algorithmic techniques. We consider parsimony a...
Miklós Csürös
RECOMB
2008
Springer
14 years 8 months ago
Detecting Disease-Specific Dysregulated Pathways Via Analysis of Clinical Expression Profiles
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
Igor Ulitsky, Richard M. Karp, Ron Shamir
RECOMB
2008
Springer
14 years 8 months ago
A Phylogenetic Approach to Genetic Map Refinement
Following various genetic mapping techniques conducted on different segregating populations, one or more genetic maps are obtained for a given species. However, recombination analy...
Denis Bertrand, Mathieu Blanchette, Nadia El-Mabro...
RECOMB
2008
Springer
14 years 8 months ago
Accounting for Non-genetic Factors Improves the Power of eQTL Studies
Abstract. The recent availability of large scale data sets profiling single nucleotide polymorphisms (SNPs) and gene expression across different human populations, has directed muc...
Oliver Stegle, Anitha Kannan, Richard Durbin, John...